Product Description

Product Overview

Mazdutide (IBI362 / LY3305677) is an advanced synthetic peptide and dual GLP-1 and glucagon receptor agonist developed from the structure of oxyntomodulin. By simultaneously engaging the glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR), Mazdutide provides a distinctive pharmacological model for studying the interaction between incretin signaling and glucagon-mediated metabolic pathways.

Its dual-receptor activity has made Mazdutide an important compound in contemporary research focused on energy balance, glucose regulation, lipid metabolism, appetite-related signaling, and metabolic physiology. Clinical development has also investigated its potential in obesity and type 2 diabetes, while laboratory-grade material remains available specifically for non-clinical research.

Scientific Profile

Mazdutide is designed to activate two complementary metabolic signaling pathways. GLP-1 receptor activity is associated with incretin signaling and glucose-regulatory processes, while glucagon receptor activation is involved in pathways governing hepatic metabolism and energy expenditure.

This combination distinguishes Mazdutide from selective GLP-1 receptor agonists and from dual GIP/GLP-1 agonists, providing researchers with a valuable model for examining how simultaneous incretin and glucagon signaling influences metabolic physiology.

Mazdutide is identified by CAS No. 2259884-03-0 and is also referenced in the literature and commercial research catalogs under the identifiers IBI362, LY3305677, and OXM-3.

Research Applications

Mazdutide is suitable for controlled laboratory research involving:

• GLP-1 receptor signaling
• Glucagon receptor pharmacology
• Incretin and glucagon pathway research
• Glucose and metabolic regulation
• Energy-balance signaling
• Lipid and hepatic metabolism
• Appetite and metabolic signaling models
• Comparative research involving multi-receptor agonists
• Peptide–receptor interaction studies
• Preclinical metabolic research

Product Specifications

• Product: Mazdutide
• Alternative identifiers: IBI362 / LY3305677 / OXM-3
• CAS Number: 2259884-03-0
• Classification: Synthetic metabolic research peptide
• Target profile: GLP-1 receptor / glucagon receptor dual agonist
• Common research formats: 5 mg, 10 mg, and larger quantities
• Purity: Batch-specific; verify the applicable COA
• Storage: Follow the supplier’s batch-specific storage requirements; one established research supplier specifies −20°C storage.

For professional research applications, each batch should be accompanied by appropriate analytical documentation confirming identity, purity, and relevant quality-control parameters.

Quality & Research Positioning

Mazdutide represents a next-generation research compound for laboratories investigating the convergence of incretin and glucagon biology. Its dual-receptor mechanism provides a particularly useful platform for comparative studies examining how different receptor combinations influence metabolic signaling and energy regulation.