Product Description

Product Overview

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome. Unlike conventional peptides encoded by nuclear DNA, MOTS-c originates from a short open reading frame within the mitochondrial 12S rRNA region, making it a distinctive research subject in the fields of mitochondrial biology and metabolic regulation.

MOTS-c has attracted substantial scientific interest for its relationship with cellular energy regulation, metabolic signaling, mitochondrial function, and cellular adaptation to metabolic stress. Research has particularly focused on its interactions with pathways associated with AMPK signaling and metabolic homeostasis, making it a valuable compound for experimental studies of mitochondrial-derived signaling.

Scientific Profile

MOTS-c consists of the sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR) and has a molecular weight of approximately 2,174.6 Da. Its unique mitochondrial origin distinguishes it from conventional nuclear-encoded peptide hormones and growth factors.

Experimental research has investigated MOTS-c in relation to AMPK-associated signaling, glucose and energy metabolism, cellular stress responses, mitochondrial communication, and metabolic adaptation. These characteristics have positioned MOTS-c as an increasingly relevant model for studying the relationship between mitochondrial signaling and cellular physiology.

Research Applications

MOTS-c is particularly relevant to controlled laboratory research involving:

• Mitochondrial-derived peptide biology
• Mitochondrial signaling and communication
• AMPK-related metabolic signaling
• Cellular energy homeostasis
• Glucose and lipid metabolism
• Metabolic stress and cellular adaptation
• Mitochondrial physiology
• Exercise and metabolic-response research
• Peptide–cell signaling studies
• Structure–activity relationship investigations

Product Specifications

• Product: MOTS-c
• Full designation: Mitochondrial Open Reading Frame of the 12S rRNA-c
• Classification: Mitochondrial-derived peptide
• Sequence: MRWQEMGYIFYPRKLR
• Length: 16 amino acids
• CAS Number: 1627580-64-6
• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
• Molecular Weight: approximately 2,174.6 g/mol
• Typical research format: Lyophilized powder
• Common research quantities: 5 mg, 10 mg, 30 mg, 40 mg
• Purity: Batch-specific; ≥99% preparations are available from research suppliers
• Analytical verification: HPLC/UPLC and mass spectrometry, depending on supplier and batch

For professional research applications, the exact sequence, purity, quantity, analytical results, and storage requirements should be verified against the batch-specific Certificate of Analysis (COA).

Quality & Research Positioning

MOTS-c is an increasingly prominent research compound for laboratories investigating the emerging field of mitochondrial-derived signaling peptides. Its defined 16-amino-acid sequence, mitochondrial origin, and relationship to metabolic signaling make it particularly suitable for controlled biochemical, cellular, and molecular research.

A premium research-grade preparation should be supplied with clear lot identification and appropriate analytical documentation confirming peptide identity and purity. Current U.S. research listings demonstrate that professionally characterized MOTS-c is commonly supplied as a lyophilized research material with third-party or supplier analytical testing.