Product Description

Product Overview

LL-37 is a naturally occurring human antimicrobial peptide and the only known cathelicidin expressed in humans. It is the mature 37-amino-acid peptide derived from the precursor protein human cathelicidin antimicrobial protein 18 (hCAP18/CAMP). Its distinctive cationic and amphipathic structure makes LL-37 an extensively studied molecule in antimicrobial, immunological, cellular, and tissue-biology research.

LL-37 is particularly notable for its ability to interact with biological membranes and microbial surface components. Beyond direct antimicrobial activity, research has investigated its involvement in innate immune signaling, inflammatory responses, cell migration, angiogenesis, and tissue-repair mechanisms, making it a versatile research peptide for both microbiological and cellular studies.

Scientific Characteristics

LL-37 consists of 37 amino acid residues and has a molecular weight of approximately 4.5 kDa. It is a linear, cysteine-free peptide that adopts an amphipathic α-helical conformation when interacting with membrane environments. Its positively charged character facilitates interactions with negatively charged biological membranes and microbial components.

These structural characteristics have made LL-37 an important model peptide for investigating membrane–peptide interactions, antimicrobial mechanisms, host-defense pathways, and peptide-mediated cellular signaling.

Research Applications

LL-37 is commonly investigated in controlled laboratory research involving:

• Antimicrobial peptide activity
• Host innate immune defense mechanisms
• Gram-positive and Gram-negative bacterial interactions
• Microbial membrane disruption
• Biofilm-related research
• Immune and inflammatory signaling
• Cell migration and wound-repair models
• Angiogenesis and cellular response studies
• Peptide–membrane interaction studies
• Structure–activity relationship research

Research literature also describes LL-37 as a multifunctional peptide whose biological effects extend beyond direct antimicrobial activity, providing opportunities for investigation across microbiology, immunology, molecular biology, and cellular physiology.

Product Specifications

• Product: LL-37
• Classification: Human cathelicidin / antimicrobial peptide
• Length: 37 amino acids
• Molecular weight: Approximately 4.5 kDa
• CAS: 154947-66-7
• Typical research format: Lyophilized peptide
• Purity: Batch-specific; commonly offered at ≥99%
• Documentation: Certificate of Analysis (COA), with HPLC/MS testing where provided

For professional laboratory use, the exact peptide quantity, purity, analytical results, endotoxin specifications, and batch information should be verified against the accompanying Certificate of Analysis.

Quality & Research Positioning

A high-quality LL-37 research preparation should provide clear batch identification and analytical documentation supporting peptide identity and purity. Current U.S. research-market listings commonly offer LL-37 in 5 mg formats with HPLC and/or mass-spectrometry documentation.